mesenchymal stem cells (mscs) Things To Know Before You Buy
IDO is often a price-limiting enzyme for degrading tryptophan (Trp) to N-formylkynurenine. besides the cell–mobile Get hold of prerequisite for MSC to induce T-cell tolerance, the culture medium also inhibits the proliferation of activated T lymphocytes, a paracrine effect that partly depends on the expression of IDO.188 The IDO-mediated conversi